Senior Research Fellow
Center of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine, The First Affiliated Hospital of Jinan University, Guangzhou
Sep. 2021 – Present

• Leading research in radio synthesis, PET tracer development, translational medicine, and clinical research.
• Developing synthetic routes for complex molecules and managing radiopharmaceutical projects from development to cGMP production.
• Collaborating with departments for clinical research on novel PET tracers for neurological disorders and other diseases.

Post-doctoral Research Fellow (Supervisor: Prof. XU, Hao)
Department of Nuclear Medicine, The First Affiliated Hospital of Jinan University, Guangzhou
Jul. 2019 – Jul. 2021

• Trained in radiochemistry, focusing on synthesizing and managing radioisotopes for pharmaceutical quality and safety.
• Applied research in clinical translational medicine, bridging lab work to clinical applications.

 Research Experience

 A.Development of PET Tracers/Radio Pharmacy

1. Norepinephrine Transporter Targeted Tracer 18F-mFBG
   • Optimized labeling conditions, achieving a 17.8% radiochemical yield and >97% radiochemical purity within 70 mins.
   • Established SOP for clinical production, producing over 30 batches for more than 200 patients.
2. Multi-functional Imaging Probe for Cu(II)
   • Designed and synthesized Cu(II)-specific probes for fluorescence and 19F MR imaging.
   • Applied the 18F-isotopologue to PET imaging in cynomolgus macaques.
3. Vasopressin 1a Receptor Targeted Tracer
   • Developed an F-18 labeled PET tracer with high affinity for V1a receptor.
   • Conducted PET imaging and kinetic modeling studies in rhesus monkeys.
4. TSPO Polymorphism-insensitive PET Tracers
   • Synthesized ligands for TSPO, demonstrating low sensitivity to TSPO rs6971 polymorphism.
   • Conducted PET imaging studies in rhesus monkeys and MCAO animal models.
5. 11C-labeled Tracers for mGlu2 and FAAH
   • Contributed to the development and analysis of 11C-labeled PET tracers for mGlu2 and FAAH.
6. New Synthons and Radiolabeling Strategies
   • Synthesized [18F]difluorocarbene and [18F]fluoro-[di-deutero]methyl tosylate, implementing automated radiolabeling programs.

B. Development of Fluorescent Probes

1. Eu(III) Complex as Fluorescent Probe for Paralytic Shellfish Toxins
   • Designed and characterized europium complexes, proposing binding mechanisms using ion mobility mass spectrometry.
2. Fluorescent Chemosensors for Polyamines
   • Synthesized TPE-conjugated pentiptycene derivatives, applied for spermine detection in artificial urine.
3. Fluorescent Probes and 1H/19F MRI Contrast Agents for EBNA1 and EBV
   • Designed and synthesized Eu(III) and Gd(III) complexes for EBNA1, evaluating magnetic resonance properties.

C. Organic Syntheses

1. Total Synthesis of Natural Product (±)-basiliolide B and Its Analogues
   • Performed a 15-step synthesis sequence, including large-scale reactions.
2. Regioselective Pd-catalyzed (3+2) Cycloaddition of 2-pyrones with Vinylcyclopropanes
   • Achieved high yields and regioselectivity, broadening substrate scope for synthesis.