Senior Research Fellow
Center of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine, The First Affiliated Hospital of Jinan University, Guangzhou
Sep. 2021 – Present
- Leading research in radio synthesis, PET tracer development, translational medicine, and clinical research.
- Developing synthetic routes for complex molecules and managing radiopharmaceutical projects from development to cGMP production.
- Collaborating with departments for clinical research on novel PET tracers for neurological disorders and other diseases.
Post-doctoral Research Fellow (Supervisor: Prof. XU, Hao)
Department of Nuclear Medicine, The First Affiliated Hospital of Jinan University, Guangzhou
Jul. 2019 – Jul. 2021
- Trained in radiochemistry, focusing on synthesizing and managing radioisotopes for pharmaceutical quality and safety.
- Applied research in clinical translational medicine, bridging lab work to clinical applications.
Research Experience
A.Development of PET Tracers/Radio Pharmacy
- Norepinephrine Transporter Targeted Tracer 18F-mFBG
- Optimized labeling conditions, achieving a 17.8% radiochemical yield and >97% radiochemical purity within 70 mins.
- Established SOP for clinical production, producing over 30 batches for more than 200 patients.
- Multi-functional Imaging Probe for Cu(II)
- Designed and synthesized Cu(II)-specific probes for fluorescence and 19F MR imaging.
- Applied the 18F-isotopologue to PET imaging in cynomolgus macaques.
- Vasopressin 1a Receptor Targeted Tracer
- Developed an F-18 labeled PET tracer with high affinity for V1a receptor.
- Conducted PET imaging and kinetic modeling studies in rhesus monkeys.
- TSPO Polymorphism-insensitive PET Tracers
- Synthesized ligands for TSPO, demonstrating low sensitivity to TSPO rs6971 polymorphism.
- Conducted PET imaging studies in rhesus monkeys and MCAO animal models.
- 11C-labeled Tracers for mGlu2 and FAAH
- Contributed to the development and analysis of 11C-labeled PET tracers for mGlu2 and FAAH.
- New Synthons and Radiolabeling Strategies
- Synthesized [18F]difluorocarbene and [18F]fluoro-[di-deutero]methyl tosylate, implementing automated radiolabeling programs.
B. Development of Fluorescent Probes
- Eu(III) Complex as Fluorescent Probe for Paralytic Shellfish Toxins
- Designed and characterized europium complexes, proposing binding mechanisms using ion mobility mass spectrometry.
- Fluorescent Chemosensors for Polyamines
- Synthesized TPE-conjugated pentiptycene derivatives, applied for spermine detection in artificial urine.
- Fluorescent Probes and 1H/19F MRI Contrast Agents for EBNA1 and EBV
- Designed and synthesized Eu(III) and Gd(III) complexes for EBNA1, evaluating magnetic resonance properties.
C. Organic Syntheses
- Total Synthesis of Natural Product (±)-basiliolide B and Its Analogues
- Performed a 15-step synthesis sequence, including large-scale reactions.
- Regioselective Pd-catalyzed (3+2) Cycloaddition of 2-pyrones with Vinylcyclopropanes
- Achieved high yields and regioselectivity, broadening substrate scope for synthesis.