Research Interests:
- Nanotechnology in Drug Delivery: Developing nanoparticle-based systems for targeted drug delivery, especially for cancer therapy and inner ear diseases.
- Ototoxicity Prevention: Creating strategies to prevent and mitigate chemotherapy-induced hearing loss.
- Planar Cell Polarity: Exploring the role of scaffold proteins like Rack1 in inner ear cellular polarity.
- Blood-Labyrinth Barrier: Modulating barrier permeability to improve drug delivery to the inner.
Major Academic Achievements:
- Anti-Tumor Therapy: Developed PEGylated polylactic acid nanoparticles for slow-release, targeted anti-tumor therapy, significantly improving efficacy compared to non-targeted methods. Published in Biomaterials and Cancer Biol Ther.
- Inner Ear Inflammation and Deafness Prevention: Investigated silk fibroin protein as a carrier for inner ear drugs, demonstrating its safety and effectiveness. Published in J Nanobiotechnology and Int J Nanomedicine.
- Planar Cell Polarity: Researched the role of Rack1 in inner ear cell polarity, with results to be published in Development.
- DNA Nanostructures: Currently researching novel DNA nanostructures as drug and gene carriers for inner ear diseases, with ongoing studies to be submitted to ACS Nano.
Professional Skills:
- Grant Writing: Experienced in preparing and concluding national natural science fund proposals.
- Scientific Writing: Published nearly 20 SCI-indexed papers as first and corresponding author.
- Drug Preparation: Proficient in conventional pharmaceutical preparations and new drug delivery systems, including liposomes and nanoparticles.
- Molecular Biology: Expertise in protein extraction, DNA/RNA isolation, quantitative analysis, Western blotting, RT-PCR, and PCR.
Publications Top Noted:
Title: Engineering nanoprobes for magnetic resonance imaging of brain diseases
- Authors: Zhang, J., Yu, L., Yu, M., Chen, Y., and Zhang, J
- Journal:Chemical Engineering Journal
- Year: 2024
- Citations: 1
Title: Intrinsic mechanism and pharmacologic treatments of noise-induced hearing loss
- Authors: Xu, K., Xu, B., Gu, J., Yu, D., Chen, Y.
- Journal: Theranostics
- Year: 2023
- Citations: 3
Title: An enhanced antioxidant strategy of astaxanthin encapsulated in ROS-responsive nanoparticles for combating cisplatin-induced ototoxicity
- Authors: Gu, J., Wang, X., Chen, Y., Yu, D., Wu, H.
- Journal: Journal of Nanobiotechnology
- Year: 2022
- Citations: 20
Title: The disruption and hyperpermeability of blood-labyrinth barrier mediates cisplatin-induced ototoxicity
- Authors: Gu, J., Tong, L., Lin, X., Wang, X., Yu, D.
- Journal: Toxicology Letters
- Year: 2022
- Citations: 13
Title: Current Strategies to Combat Cisplatin-Induced Ototoxicity
- Authors: Yu, D., Gu, J., Chen, Y., Wang, X., Wu, H.
- Journal: Frontiers in Pharmacology
- Year: 2020
- Citations: 51