Mr. Mehdi Heidari Horestani | Cancer Genetics | Best Researcher Award
Jena University Hospital, Germany
Profiles
Summary
Mr. Heidari Horestani is a dedicated researcher specializing in molecular genetics and cancer biology. He currently works at the Institute of Human Genetics, Jena University Hospital, where he supervises Master’s students and conducts cutting-edge research on hormone-induced cellular senescence in prostate cancer cells. With extensive experience in both wet-lab and dry-lab techniques, he is passionate about advancing knowledge in cancer biology and molecular medicine.
Education
- Ph.D. in Molecular Medicine (Molecular Genetics), Friedrich Schiller University, Jena University Hospital (2021–present)
Thesis: Identifying the Androgen Receptor-BHLHE40-signaling axis in prostate cancer
Supervisor: Prof. Dr. Aria Baniahmad - M.Sc. in Genetics, Shahid Beheshti University, Tehran, Iran (2015–2018)
Thesis: Polymorphism changes of TAFL7 gene in spermatogenesis inhibition
Supervisor: Prof. Dr. Masoud Sheidai - B.Sc. in Cellular and Molecular Biology (Genetics), Nour Danesh Institute, Isfahan, Iran (2010–2014)
Research Experience
- Lab Research Assistant, Jena University Hospital, Institute of Human Genetics (2021–present)
Supervised Master’s students and conducted cancer-related research, including animal models and molecular techniques. - Lab Research Assistant, Shahid Beheshti University, Tehran, Iran (2018–2021)
Supervised Bachelor and Master’s students in cancer and genetic research under Prof. Dr. Sheidai.
Skills
- Tumor xenograft models, cancer cell culture, gene knockdown/overexpression, immunofluorescence, RNA/Protein extractions.
- Bioinformatics workflows in R, data visualization, SPSS, and SnapGene.
Research Interests
- Cancer biology and molecular genetics, specifically focusing on cellular senescence in prostate cancer cells.
- Tumor xenograft models, gene expression analysis, and cancer spheroid generation.
- Advanced molecular techniques like RNA-seq, ChIP-seq, and gene editing (siRNA, plasmid transfection).
Awards & Certifications
- DAAD Scholarship for doctoral studies in Germany.
- FELASA certificate for conducting animal experiments.
Publications
H2AJ Is a Direct Androgen Receptor Target Gene That Regulates Androgen-Induced Cellular Senescence and Inhibits Mesenchymal Markers in Prostate Cancer Cells
- Authors: Mehdi Heidari Horestani, Golnaz Atri Roozbahani, Aria Baniahmad
- Journal: Cancers
- Year: 2025
The protein composition of exosomes released by prostate cancer cells is distinctly regulated by androgen receptor-antagonists and-agonist to stimulate growth of target cells
- Authors: Golnaz Atri Roozbahani, Miriam Kokal-Ribaudo, Mehdi Heidari Horestani, Thanakorn Pungsrinont, Aria Baniahmad
- Journal: Cell Communication and Signaling
- Year: 2024
The clock gene BHLHE40 and atypical CCNG2 control androgen-induced cellular senescence as a novel tumor suppressive pathway in prostate cancer
- Authors: Mehdi Heidari Horestani, Golnaz Atri Roozbahani, Aria Baniahmad
- Journal: Journal of Experimental & Clinical Cancer Research
- Year: 2024
The oncogenic lncRNA MIR503HG suppresses cellular senescence counteracting supraphysiological androgen treatment in prostate cancer
- Authors: Julia Kallenbach, Mahdi Rasa, Mehdi Heidari Horestani, Golnaz Atri Roozbahani, Katrin Schindler, Aria Baniahmad
- Journal: Journal of Experimental & Clinical Cancer Research
- Year: 2024
Functional circuits of LYL1 controlled by supraphysiological androgen in prostate cancer cells to regulate cell senescence
- Authors: Mehdi Heidari Horestani, Katrin Schindler, Aria Baniahmad
- Journal: Cell Communication and Signaling
- Year: 2024
Mr. Mehdi Heidari Horestani | Cancer Genetics | Best Researcher Award