Taipei Medical University-Taiwan
Author Profile
Early Academic Pursuits
Prof. Yao-An Shen, PhD, embarked on his academic journey with a strong foundation in the biomedical sciences. In 2009, he earned his Master's degree in the Department of Life Sciences and Institute of Genome Sciences at National Yang-Ming University in Taipei, Taiwan. He continued his academic pursuits, culminating in a Ph.D. in 2015 from the Institute of Biochemistry and Molecular Biology at National Yang-Ming University.
Professional Endeavors
Prof. Shen's professional trajectory showcases a commitment to global collaboration and diverse research experiences. Following his Ph.D., he engaged in postdoctoral research at prestigious institutions, including the Departments of Pathology, Oncology, and Gynecology & Obstetrics at Johns Hopkins Medical Institutions in Baltimore, MD, USA. He further expanded his expertise by working in the Department of Biomedical Engineering at National Yang-Ming University and the Section of Gynecologic Oncology at Taipei Veterans General Hospital.
In 2016, Dr. Shen returned to Taipei Medical University, where he currently serves as an Assistant Professor in the Department of Pathology. His role encompasses teaching a range of subjects, from General Biology to Cancer Stem Cell Biology, reflecting his interdisciplinary approach to education.
Contributions and Research Focus On Cancer Stem Cell Research
Prof. Shen's research portfolio highlights his expertise in translational research, cell therapy, cancer metabolism, cancer stem cell research, induced pluripotent stem cell research, and nanomedicine. His work involves investigating small molecule inhibitors targeting GLS and PBX1 for cancer therapeutics, exploring the therapeutic applications of stem cells for regenerative medicine, and studying the metabolic reprogramming of cancer stem cells.
One of his significant contributions lies in the development of prodrugs and dual-target drugs for the PBX1 transcription factor, demonstrating a keen interest in advancing cancer therapeutics. His involvement in licensing and technology transfer, with eight patents related to cell expansion and metabolic selection techniques, further emphasizes the practical applications of his work.
Accolades and Recognition
Prof. Shen's dedication to advancing scientific knowledge has been acknowledged through numerous grants and awards. Notable among these are grants from the National Science and Technology Council and the Ministry of Science and Technology, emphasizing the recognition of his research contributions.
His excellence has also been recognized through awards such as the Young Investigator Award at the International Symposium on Mitochondria, showcasing his contributions to mitochondrial research and medicine.
The impact of this research extends beyond the laboratory, influencing the development of cutting-edge cancer therapeutics. With a focus on small molecule inhibitors targeting key factors, Yao An-Shen's contributions are shaping the landscape of personalized and effective treatment strategies.
Impact and Influence
Prof. Shen's publications in esteemed journals, including ACS Nano, Journal of Experimental & Clinical Cancer Research, and Blood, underscore his impact on the scientific community. His research on cancer treatment paradigms, stem cell-derived exosomes, and metal-based nanoenhancers for particle therapy reflects a commitment to cutting-edge advancements.
Cancer Stem Cell Research, spearheaded by Yao An-Shen, stands at the forefront of innovative medical exploration. Focused on understanding the unique properties of cancer stem cells, this research aims to unravel the molecular intricacies driving tumorigenesis.
Legacy and Future Contributions
Prof. Yao-An Shen, with a rich background in academia and research, has laid the foundation for future breakthroughs in cancer therapeutics, stem cell applications, and nanomedicine. His ongoing grants and projects signal a commitment to continued exploration and innovation in the field, ensuring a lasting legacy in advancing medical knowledge and treatments.
Yao An-Shen's work in Cancer Stem Cell Research has led to pioneering discoveries in biomarker identification, unveiling potential therapeutic targets. By investigating metabolic reprogramming, his team has unlocked new avenues for developing precision medicine in the fight against cancer.
Notable Publication