Early Academic Pursuits
Dr. Pan Wang embarked on his academic journey in clinical medicine, earning his Bachelor of Science (B.S.) degree from Jinzhou Medical University in 2009. Driven by a deep interest in neurobiology and human structure, he pursued a Master of Science (M.S.) in Human Anatomy and Embryology from the same university, graduating in 2012. To deepen his expertise, he continued his studies at China Medical University, where he obtained his Ph.D. in Human Anatomy and Embryology in 2020. His academic background laid a solid foundation for his subsequent contributions to neuropathological research.
Professional Endeavors
Following his academic training, Dr. Wang served as an Assistant Researcher at the Department of Neurobiology, Jinzhou Medical University, from 2012 to 2016. Since 2021, he has been contributing to translational neuroscience as a Postdoctoral Researcher in the Department of Pathology at the First Affiliated Hospital of Zhejiang University School of Medicine. His work there integrates advanced molecular biology with clinical applications in neurodegenerative diseases.
Contributions and Research Focus
Dr. Wang’s research primarily explores the molecular and cellular mechanisms underlying Alzheimer’s disease (AD) and Parkinson’s disease (PD). His studies span from the spatially resolved hippocampal atlas in AD to the role of astrocytic extracellular vesicles, melatonin signaling pathways, and the gut-brain axis in PD. Notably, his investigation into VEGFA-mediated blood-brain barrier disruption and the Notch1 signaling pathway has opened new avenues for understanding neuroinflammation and neuroprotection. He is particularly noted for his research on melatonin’s neuroprotective effects and the involvement of Reelin-Dab1 and Musashi1/Notch1/Hes1 pathways.
Impact and Influence
Dr. Wang’s work has been widely published in top-tier journals such as Neuron, Translational Neurodegeneration, Glia, Alzheimer’s Research & Therapy, and Movement Disorders. His 2025 publication in Neuron on spatially resolved molecular diagnostics in the Alzheimer’s hippocampus marks a significant leap in spatial transcriptomics applied to neurodegeneration. His publications are gaining increased recognition in the neuroscience community for bridging the gap between pathology and molecular diagnostics.
Academic Citations and Highlights
Dr. Wang’s research has accumulated numerous citations, with multiple papers indexed in PubMed, PMC, and high-impact journals. His collaborative studies with leading researchers from China and abroad have contributed to multi-authored publications reflecting both individual excellence and team-based innovation. His representative works include:
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Neuron (2025): Molecular pathways in Alzheimer’s hippocampal atlas.
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Translational Neurodegeneration (2023): α-Synuclein in astrocytic vesicles.
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Movement Disorders (2024): Erythrocytic α-Synuclein and gut-brain axis.
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Neural Regeneration Research (2021) and Molecular Biology Reports (2023): Effects of melatonin on microvessels and Notch1 signaling.
Technical Skills
Dr. Wang is proficient in a broad range of biomedical techniques, including immunohistochemistry, molecular imaging, fluorescence microscopy, Western blot, PCR, and extracellular vesicle isolation. He also applies animal models of Alzheimer’s and Parkinson’s diseases to study neurodegeneration at the histological and molecular levels. His methodological rigor and innovation have earned him recognition in translational neuroscience.
Teaching Experience
During his tenure at Jinzhou Medical University, Dr. Wang engaged in mentoring and teaching undergraduate and graduate students in neurobiology and anatomy. He has supervised laboratory sessions, guided research projects, and participated in curriculum development in neuroanatomy and pathology.
Legacy and Future Contributions
With a robust background in both basic neuroscience and clinical pathology, Dr. Wang is poised to continue contributing to the advancement of diagnostic and therapeutic approaches for neurodegenerative diseases. His future research aims to integrate omics-based diagnostics with personalized neurotherapies, especially for early-stage Alzheimer’s and Parkinson’s. Dr. Wang envisions building a multidisciplinary lab that combines pathology, genomics, and bioinformatics to unravel disease heterogeneity and progression.